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rac1  (Addgene inc)


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    Structured Review

    Addgene inc rac1
    Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) are activated following a cascade of intracellular signaling imposed by binding transmembrane receptors, such as receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), or integrins (INTs), at the extracellular matrix (ECM). RhoGEFs promote activation of Rho-GTPases, which regulate multiple signal transduction pathways that regulate actin reorganization. The RhoA pathway is required for Myosin II activation, whereas the Rac pathway <t>(Rac1/2)</t> is required for actin polymerization. Crosstalk between these pathways allows for actomyosin stability and contractility throughout the cytoskeleton.
    Rac1, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rac1/product/Addgene inc
    Average 93 stars, based on 14 article reviews
    rac1 - by Bioz Stars, 2026-04
    93/100 stars

    Images

    1) Product Images from "Human cell F-actin density differentially influences trogocytosis and phagocytosis by Entamoeba histolytica"

    Article Title: Human cell F-actin density differentially influences trogocytosis and phagocytosis by Entamoeba histolytica

    Journal: bioRxiv

    doi: 10.64898/2026.03.17.712427

    Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) are activated following a cascade of intracellular signaling imposed by binding transmembrane receptors, such as receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), or integrins (INTs), at the extracellular matrix (ECM). RhoGEFs promote activation of Rho-GTPases, which regulate multiple signal transduction pathways that regulate actin reorganization. The RhoA pathway is required for Myosin II activation, whereas the Rac pathway (Rac1/2) is required for actin polymerization. Crosstalk between these pathways allows for actomyosin stability and contractility throughout the cytoskeleton.
    Figure Legend Snippet: Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) are activated following a cascade of intracellular signaling imposed by binding transmembrane receptors, such as receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), or integrins (INTs), at the extracellular matrix (ECM). RhoGEFs promote activation of Rho-GTPases, which regulate multiple signal transduction pathways that regulate actin reorganization. The RhoA pathway is required for Myosin II activation, whereas the Rac pathway (Rac1/2) is required for actin polymerization. Crosstalk between these pathways allows for actomyosin stability and contractility throughout the cytoskeleton.

    Techniques Used: Binding Assay, Activation Assay, Transduction



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    Image Search Results


    Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) are activated following a cascade of intracellular signaling imposed by binding transmembrane receptors, such as receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), or integrins (INTs), at the extracellular matrix (ECM). RhoGEFs promote activation of Rho-GTPases, which regulate multiple signal transduction pathways that regulate actin reorganization. The RhoA pathway is required for Myosin II activation, whereas the Rac pathway (Rac1/2) is required for actin polymerization. Crosstalk between these pathways allows for actomyosin stability and contractility throughout the cytoskeleton.

    Journal: bioRxiv

    Article Title: Human cell F-actin density differentially influences trogocytosis and phagocytosis by Entamoeba histolytica

    doi: 10.64898/2026.03.17.712427

    Figure Lengend Snippet: Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) are activated following a cascade of intracellular signaling imposed by binding transmembrane receptors, such as receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), or integrins (INTs), at the extracellular matrix (ECM). RhoGEFs promote activation of Rho-GTPases, which regulate multiple signal transduction pathways that regulate actin reorganization. The RhoA pathway is required for Myosin II activation, whereas the Rac pathway (Rac1/2) is required for actin polymerization. Crosstalk between these pathways allows for actomyosin stability and contractility throughout the cytoskeleton.

    Article Snippet: For creation of Jurkat cell CRISPRi knockdown mutants, single guide RNAs (sgRNAs) to target human CFL1, MYPT1, Rac1, Rac2, RhoA, ROCK1, and ROCK2 genes were selected from published data from the Human Genome-wide CRISPRi-v2 Libraries (gift from Sean R. Collins, University of California, Davis, and deposited by Jonathan S. Weissman, University of California, San Francisco; Addgene pooled libraries #83969, #1000000090) ( ).

    Techniques: Binding Assay, Activation Assay, Transduction